3-(4-Fluorophenyl)-6-methyl-2,3-dihydro-1H-inden-1-one → HCID 13154734, compound

HRID 325865Notes

Reaction equation

HRID 325865 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:16]3[C:11](=[CH:12][C:13]([CH3:17])=[CH:14][CH:15]=3)[C:10](=[O:18])[CH2:9]2)=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[C:16]3[C:11](=[CH:12][C:13]([CH3:17])=[CH:14][CH:15]=3)[CH:10]([OH:18])[CH2:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 30189233-(4-Fluorophenyl)-6-methyl-2,3-dihydro-1H-inden-1-oneHCID 4311764Sodium borohydride

Product 1

HCID 13154734HCID 13154734, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 225 grams of 3-(4'-fluorophenyl)-6-methyl-1-indanone in 2.3 liters of methanol was treated with 90 grams of sodium borohydride while cooling and stirring and keeping the temperature below 20 degrees Centigrade.

Workup

  1. temperaturewhile cooling
  2. customthe temperature below 20 degrees Centigrade

Sources & evidence

ORD record
ord-22e2033534814668bd3c2ff54dd5aa12
Source dataset
uspto-grants-1984_04
Patent number
US04443448

Reaction notes

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