1,4-Dibromobutane → HCID 13083323, compound

Participants

Reaction Steps

2-[1-(4-Chlorophenyl)cyclobutyl]ethylamine (12 g) prepared as described in Example 1, 1,4-dibromobutane (12.4 g) and anhydrous sodium carbonate (14.3 g) were mixed in xylene (100 ml) and the mixture heated under reflux with stirring for sixteen hours. The mixture was cooled, filtered and the xylene removed by evaporation to give a residue which on distillation gave N-2-[1-(4-chlorophenyl)cyclobutyl]ethylpyrrolidine (b.p. 148°-150°/1.5 mm Hg) (Formula 1 R1,R2 =H; R3 and R4 together with the nitrogen atom forming a pyrrolidine ring; R5 =4-Cl; R6, R7 and R8 =H).

Provenance & Evidence