6-(1-ethyl-4-phenyl-1H-imidazol-5-yl)-4-(methylthio)thieno[2,3-d]pyrimidine → 2-(1-Ethyl-4-phenyl-1H-imidazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-amine

HRID 32587Notes

Reaction equation

HRID 32587 reaction equation
[CH2:1]([N:3]1[C:7]([C:8]2[S:9][C:10]3[N:11]=[CH:12][N:13]=[C:14](SC)[C:15]=3[N:16]=2)=[C:6]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:5]=[CH:4]1)[CH3:2].C([N:27]1C(C2SC3N=CN=C(SC)C=3C=2)=C(C2C=CC=CC=2)N=C1)C>>[CH2:1]([N:3]1[C:7]([C:8]2[S:9][C:10]3[N:11]=[CH:12][N:13]=[C:14]([NH2:27])[C:15]=3[N:16]=2)=[C:6]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:5]=[CH:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 691949276-(1-ethyl-4-phenyl-1H-imidazol-5-yl)-4-(methylthio)thieno[2,3-d]pyrimidineHCID 691960022-(1-ethyl-4-phenyl-1H-imidazol-5-yl)-7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine2×

Product 1

HCID 103140492-(1-Ethyl-4-phenyl-1H-imidazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-amine

Procedure

The title compound was prepared by a similar process to that described for Example 56 but using 2-(1-ethyl-4-phenyl-1H-imidazol-5-yl)-7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine (Intermediate 78) in place of 6-(1-ethyl-4-phenyl-1H-imidazol-5-yl)-4-(methylthio)thieno-[2,3-d]pyrimidine (Intermediate 70). Yellow solid (60 mg, 64%);

Sources & evidence

ORD record
ord-6389ee2db2dc419aa35c4741736e96da
Source dataset
uspto-grants-2008_09
Patent number
US07427616B2

Reaction notes

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