反应详情

温度

175 °C

1-[1-(4-chlorophenyl)cyclobutyl]propan-2-one prepared as described in Example 3 (25 g) and 98% formic acid (10 ml) were added to formamide (22 ml) at 160° C. The temperature was raised to 175° C. and maintained at this temperature for sixteen hours. The mixture was cooled, extracted with dichloromethane. The extract was washed with water and evaporated to give a gum which was crystallised from petroleum ether (b.p. 40°-60° C.) to give N-formyl-2-[1-(4-chlorophenyl)cyclobutyl]-1-methylethylamine (m.p. 71°-73° C.).

1. temperaturemaintained at this temperature for sixteen hours
2. temperatureThe mixture was cooled
3. extractionextracted with dichloromethane
4. washThe extract was washed with water
5. customevaporated
6. customto give a gum which
7. customwas crystallised from petroleum ether (b.p. 40°-60° C.)