Hydroxylamine, sulfate (1:1) → HCID 73165579, compound

HRID 325877Notes

Reaction equation

HRID 325877 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:13][C:14](=O)[CH2:15][CH3:16])[CH2:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].S(O)(O)(=O)=O.[NH2:23][OH:24].C([O-])(=O)C.[Na+]>O>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:13][C:14](=[N:23][OH:24])[CH2:15][CH3:16])[CH2:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

5

Reactant 3

HCID 159255Hydroxylamine, sulfate (1:1)HCID 517045Sodium AcetateHCID 13083382HCID 13083382, compound

Product 1

HCID 73165579HCID 73165579, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1-[1-(3,4-dichlorophenyl)cyclobutyl]butan-2-one (4.3 g) prepared as described above, hydroxylamine sulphate (2.65 g), sodium acetate (4.0 g), industrial methylated spirit (56 ml) and water (23 ml) was stirred at ambient temperature for sixteen hours. The reaction mixture was extracted with ether. The ether extract was washed with water, dried and evaporated to give a solid which was recrystallised from petroleum ether (b.p. 80°-100° C.) to give 1-[1-(3,4-dichlorophenyl)cyclobutyl]butan-2-one oxime (m.p. 106°-110° C.).

Workup

  1. customprepared
  2. extractionThe reaction mixture was extracted with ether
  3. extractionThe ether extract
  4. washwas washed with water
  5. customdried
  6. customevaporated
  7. customto give a solid which
  8. customwas recrystallised from petroleum ether (b.p. 80°-100° C.)

Sources & evidence

ORD record
ord-8f1f0f47f4cc4cc887f16bb09d681bfc
Source dataset
uspto-grants-1984_04
Patent number
US04443449

Reaction notes

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