反应详情

温度

110 °C

A mixture of 29.9 g of 4-(diphenylmethylene)-piperidine, 36.3 g of 2-[2-(2-chloroethoxy)ethoxy]-acetamide and 18 g of sodium carbonate in 80 ml of xylene is heated for 20 hours at a temperature of from 90°to 110° C. Thereafter, 80 ml of benzene are added thereto. The precipitate obtained is filtered off and the organic phase is extracted with a dilute solution of hydrochloric acid (20 ml of concentrated hydrochloride acid and 80 ml of water). After the addition of 30 ml of a concentrated solution of sodium hydroxide and extraction with benzene, the benzene solution obtained is washed, dried over anhydrous potassium carbonate and the benzene evaporated in vacuo. The 2-[2-[2-[4-(diphenylmethylene)-1-piperidinyl]ethoxy]ethoxy]-acetamide obtained is used as such for the preparation of the corresponding acid (see Example 3.4).

1. customThe precipitate obtained
2. filtrationis filtered off
3. extractionthe organic phase is extracted with a dilute solution of hydrochloric acid (20 ml of concentrated hydrochloride acid and 80 ml of water)
4. additionAfter the addition of 30 ml of a concentrated solution of sodium hydroxide and extraction with benzene
5. customthe benzene solution obtained
6. washis washed
7. dry with materialdried over anhydrous potassium carbonate
8. customthe benzene evaporated in vacuo