Acetone → DL-Carnitine

Participants

Reaction Steps

Carnitine hydrochloride (1.98 g; 0.01 moles) was dissolved in 5 cc of trifluoroacetic acid and to the solution propionyl chloride (1 cc; 0.01 moles) was added. The resulting solution was kept at 40°-45° C. overnight. The solution was then cooled to room temperature and acetone (50 cc) was added thereto keeping under stirring for 2 hours. The solid precipitate which formed (carnitine) was filtered off, 30 cc of ethyl ether were added to the filtrate and the resulting mixture was kept under stirring at 0° C. The solid precipitate which formed was filtered off and crystallized with ethanol-acetone-ethyl ether.

Provenance & Evidence