HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Fluorobenzoyl)propyl chloride → 4-[4-(1-Naphthalenyloxy)-1-piperidyl]-1-(4-fluorophenyl)-1-butanone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Fluorobenzoyl)propyl chloride | HCID 19750 | — |
| Reactant | 4-Chlorobutyrophenone | HCID 253533 | — |
| Reactant | 2-Naphthyl 4-Piperidinyl Ether Hydrochloride | HCID 18423350 | — |
| Reactant | 1-Naphthyl 4-piperidinyl ether hydrochloride | HCID 20463239 | — |
| Product | 4-[4-(1-Naphthalenyloxy)-1-piperidyl]-1-(4-fluorophenyl)-1-butanone hydrochloride | HCID 20463233 | — |
Reaction Steps
When in the procedure of Example 13, 4-chloro-1-(4-fluorophenyl)-1-butanone is substituted for 4-chloro-1-phenyl-1-butanone and 4-(1-naphthalenyloxy)piperidine hydrochloride is substituted for 4-(2-naphthalenyloxy)piperidine hydrochloride, 4-[4-(1-naphthalenyloxy)-1-piperidyl]-1-(4-fluorophenyl)-1-butanone hydrochloride is produced. M.P. 220°-222.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04443462 |
| Source dataset | uspto-grants-1984_04 |
| ORD ID | ord-1ef3b6bbe8e549338cd2279f8d23a8e3 |
| Source note | uspto-grants-1984_04 |