反应详情

温度

90 °C

Sodium thiomethoxide (1.2 g) was added to a solution of 4-chlorofuro[3,2-d]pyrimidine (Intermediate 84) (1.32 g) in MeCN (100 mL). The mixture was heated to 90° C. for 60 minutes, cooled, and added to 50% sodium carbonate solution (100 ml). The resulting mixture was extracted into EtOAc (3×100 mL). The combined organics were dried (MgSO4) and the solvent removed to afford the title compound as a pale orange solid (1.21 g, 85%);

1. temperaturecooled
2. extractionThe resulting mixture was extracted into EtOAc (3×100 mL)
3. dry with materialThe combined organics were dried (MgSO4)
4. customthe solvent removed