Pyrrolidine → HCID 53893007, compound

Participants

Reaction Steps

The piperazine compound was dissolved in 150 ml of chloroform, and to the solution was added 2.30 g of pyrrolidine. The resultant mixture was stirred at room temperature for 1.5 hours. After completion of the reaction, the solvent was evaporated, and the residue was subjected to chromatography using a silica gel column and purified with a mixed solvent of chloroform and methanol (10:1), thereby obtaining 11.1 g (a stoichiometric amount) of 1-(4-hydroxycinnamoyl)-4-(pyrrolidinocarbonylmethyl)piperazine as a colorless oily substance.

Provenance & Evidence