Imidazole → HCID 6481671, compound

Participants

Reaction Steps

89.2 g 4-chlorophenacyl bromide is dissolved in 170 ml chloroform (or methylene chloride) and the solution is then added dropwise to a solution of 156 g imidazole in 600 ml chloroform (or methylene chloride, as the case may be) while maintaining the reaction mixture at about 0° to 5° C. Thereafter the mixture is continually stirred at this temperature for 4 hours, the solvent is distilled off in a rotation evaporator and the residue is treated with water. After filtering off and drying the precipitate and recrystallizing it in toluene one obtains 65 g p-chlorophenacyl imidazole or 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-1-ethanone in the form of colorless crystals having a melting point of 158° to 160° C.

Provenance & Evidence