Propylene Glycol → Skatole

HRID 325991Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:8](O)[CH:9](O)[CH3:10]>>[CH3:10][C:9]1[C:7]2[C:2](=[CH:3][CH:4]=[CH:5][CH:6]=2)[NH:1][CH:8]=1

Participants

Reactant 2

HCID 1030Propylene Glycol

HCID 6115Aniline

Product 1

HCID 6736Skatole

Procedure

Aniline and propylene glycol were reacted at a molar ratio shown in Table 17 in the same manner as described in Example 1, whereby 3-methylindole was obtained as a main product. The results are shown in the following Table 17.

Sources & evidence

ORD record: ord-4ba75ceb94fd44d5929c4c186740a5d7
Source dataset: uspto-grants-1984_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04443615

Reaction notes

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