HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 6-(1-methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylthio)furo[3,2-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 4-(Methylthio)thieno[2,3-d]pyrimidine-6-carbaldehyde | HCID 17965859 | — |
| Reactant | 4-(Methylthio)furo[3,2-d]pyrimidine-6-carbaldehyde | HCID 17965868 | — |
| Reactant | 6-(1-ethyl-4-phenyl-1H-imidazol-5-yl)-4-(methylthio)thieno[2,3-d]pyrimidine | HCID 69194927 | — |
| Product | 6-(1-methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylthio)furo[3,2-d]pyrimidine | HCID 69194926 | — |
Reaction Steps
The title compound was prepared by a similar process to that described for Intermediate 70 but using 4-(methylthio)furo[3,2-d]pyrimidine-6-carbaldehyde (Intermediate 86) in place of 4-(methylthio)thieno[2,3-d]pyrimidine-6-carbaldehyde (Intermediate 15) and methylamine in place of ethylamine. Pale yellow solid (105 mg, 54%);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427616B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-8029401632d74cbeac00e06532f2ab92 |
| Source note | uspto-grants-2008_09 |