Benzylamine → HCID 13305504, compound

HRID 326020Notes

Reaction equation

HRID 326020 reaction equation
Cl[CH:2]([CH3:21])[CH2:3][N:4]1[CH:13]=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]1=[O:20].[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>CO>[CH2:22]([NH:29][CH:2]([CH3:21])[CH2:3][N:4]1[CH:13]=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]1=[O:20])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 131876432-(2-chloropropyl)-4-phenyl-1(2H)-isoquinolone

Product 1

HCID 13305504HCID 13305504, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

29.8 g of 2-(2-chloropropyl)-4-phenyl-1(2H)-isoquinolone was mixed with 20 ml of benzylamine, and the mixture was heat-melted in a nitrogen stream. After completion of the reaction, the mixture was dissolved in methanol while hot, and the solution was poured into crashed ice. The resulting precipitate was collected by filtration, washed with water, dried and recrystallized from a mixture of ethyl acetate and petroleum ether to obtain 30.2 g (82% yield) of 2-(2-benzylaminopropyl)-4-phenyl-1(2H)-isoquinolone having a melting point of 118° C.

Workup

  1. customAfter completion of the reaction
  2. additionwas poured
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed with water
  5. customdried
  6. customrecrystallized from a mixture of ethyl acetate and petroleum ether

Sources & evidence

ORD record
ord-cc3d029767e140feab7271ba10dc3356
Source dataset
uspto-grants-1984_04
Patent number
US04443607

Reaction notes

Loading…