反应详情

36.8 g of 2-(2-benzylaminopropyl)-4-phenyl-1(2H)-isoquinolone preapred as described above, 12 g of 5% palladium-carbon, 50 ml of glacial acetic acid and 200 ml of ethanol were mixed, and the mixture was catalytically reduced while introducing hydrogen gas into the mixture at 60° to 70° C. After completion of the reduction reaction, the mixture was filtered, and the solvent was distilled off from the filtrate. The resulting residue was dissolved in 5% hydrochloric acid and the solution was washed with ethyl acetate. The aqueous layer was separated and rendered neutral with a 10% aqueous solution of sodium hydroxide. The resulting precipitate was filtered and recrystallized from a mixture of ethyl acetate and petroleum ether to obtain 20.9 g (75% yield) of 2-(2-aminopropyl)-4-phenyl-1(2H)-isoquinolone having a melting point of 104° C. as colorless prisms.

1. additionwere mixed
2. customAfter completion of the reduction reaction
3. filtrationthe mixture was filtered
4. distillationthe solvent was distilled off from the filtrate
5. dissolutionThe resulting residue was dissolved in 5% hydrochloric acid
6. washthe solution was washed with ethyl acetate
7. customThe aqueous layer was separated
8. filtrationThe resulting precipitate was filtered
9. customrecrystallized from a mixture of ethyl acetate and petroleum ether