Ammonia → HCID 20461930, compound

HRID 326033Notes

Reaction equation

HRID 326033 reaction equation
O.[NH3:2].[F:3][CH:4]([F:20])[O:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH:13]([F:15])[F:14])=[CH:8][C:7]=1[S:16](Cl)(=[O:18])=[O:17]>C(Cl)Cl>[F:3][CH:4]([F:20])[O:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH:13]([F:15])[F:14])=[CH:8][C:7]=1[S:16]([NH2:2])(=[O:18])=[O:17]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 962WaterHCID 204619272,5-Bis(difluoromethoxy)benzene-1-sulfonyl chloride

Product 1

HCID 20461930HCID 20461930, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a mixture of 30 ml of methylene chloride, 30 ml of water and 50 ml of 30% ammonia solution is slowly added a solution of 12.7 g of crude 2.5-bis(difluoromethoxy)phenylsulfonyl chloride in 150 ml of methylene chloride. The reaction mixture is stirred for 5 hours at room temperature. The organic phase is washed with water, dried over sodium sulfate and evaporated to a volume of about 40 ml. From the residue crystallise 10.7 g of 2.5-bis(difluoromethoxy)phenyl-sulfonamide with a melting point of 73°-74° C.

Workup

  1. washThe organic phase is washed with water
  2. dry with materialdried over sodium sulfate
  3. customevaporated to a volume of about 40 ml
  4. customFrom the residue crystallise 10.7 g of 2.5-bis(difluoromethoxy)phenyl-sulfonamide with a melting point of 73°-74° C.

Sources & evidence

ORD record
ord-46806a9a7b984f53b4e0ac1e25362d4d
Source dataset
uspto-grants-1984_04
Patent number
US04444583

Reaction notes

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