Triethylamine → HCID 20461929, compound

Participants

Reaction Steps

14.5 g of 2.5-bis(difluoromethoxy)phenylsulfonamide are suspended in 50 ml of absolute methylene chloride. Then 3.5 g of methyl isocyanate are added and 6.3 g of triethylamine are subsequently added dropwise over 10 minutes to form a clear solution. The solution is stirred at room temperature for a further hour, evaporated to dryness, and the residue is dissolved in 5% sodium carbonate solution. N-[2,5-bis(difluoromethoxy)phenylsulfonyl]-N'-methylurea with a melting point of 162°-165° C., is precipitated from the solution by acidification with 10% hydrochloric acid. Yield: 15.0 g.

Provenance & Evidence