Quinoline → Ethyl 2-[4-(2-bromoquinolin-4-yloxy)phenoxy]propionate

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Reaction Steps

Ethyl 2-[4-(2-bromoquinolin-4-yloxy)phenoxy]propionate (40) was prepared from 2-bromo-4-nitroquinoline (Chem Abstracts 51: 6639) and ethyl 2-(4-hydroxyphenoxy)-propionate following essentially the same procedure as that described in Example 1. The compound was isolated as a colourless oil which solidified slowly on standing. Proton magnetic resonance spectrum (CDCl3 ; δ in ppm): 8.5-7.4 (4H, m, quinoline protons); 7.1 (4H, d of d, phenyl protons); 6.6 (1H, s, C3 quinoline proton); 4.8 (1H, q, CHCH3); 4.3 (2H, q, OCH2CH3); 1.65 (3H, d, CHCH3); 1.3 (3H t, OCH2CH3).

Provenance & Evidence