Hydrochloric Acid → HCID 20461938, compound

Participants

Reaction Steps

A mixture of 2,6-dichloroquinoline (6.0 g), 4-aminophenol (3.3 g), hydrochloric acid (3 g) and ethanol (100 ml) was stirred and refluxed for 10 hours. The solvent was removed under reduced pressure and the residue partitioned between ethyl acetate and water. The ethyl acetate extracts on evaporation gave 4-[N-(6-chloro-2-quinolinyl)-amino]phenol (2.7 g) as a brown solid.

Provenance & Evidence