Potassium Carbonate → HCID 20461950, compound

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Reaction Steps

A mixture of ethyl 2-bromopropionate (0.5 g), 4-[N-(3-nitro-2-quinolinyl)amino]phenol (0.5 g), anhydrous potassium carbonate (0.3 g) and ethyl methyl ketone (20 ml) was refluxed for 4 hours. The solvent was removed under reduced pressure and the residue was partitioned between methylene chloride and water. The organic layer was dried and evaporated to give ethyl 2-{4-[N-(3-nitro-2-quinolinyl)amino]phenoxy}propionate as an orange oil which was purified by chromatography over silica gel. Proton magnetic resonance spectrum: (CDCl3, δ in ppm): 9.6 (1H, s, NH); 8.9 (1H, s, C4 quinoline proton); 7.8-7.6 (4H, m, quinoline protons); 6.8 (4H, s, phenyl protons); 4.6 (1H, q, CHCH3); 4.2 (2H, q, OCH2CH3); 1.6 (3H, d, CHCH3); 1.2 (3H, t, OCH2CH3).

Provenance & Evidence