6-(1-Methylphenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine → 6-(4-Iodo-1-methyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine

HRID 32607Notes

Reaction equation

HRID 32607 reaction equation
C[C:2]1([N:8]2[C:12]([C:13]3[S:25][C:16]4[N:17]=[CH:18][N:19]=[C:20]([S:21]([CH3:24])(=[O:23])=[O:22])[C:15]=4[CH:14]=3)=[CH:11][N:10]=[CH:9]2)C=CC=CC1.[I:26]C1N=CN(C)C=1C1SC2N=CN=C(SC)C=2C=1>>[I:26][C:11]1[N:10]=[CH:9][N:8]([CH3:2])[C:12]=1[C:13]1[S:25][C:16]2[N:17]=[CH:18][N:19]=[C:20]([S:21]([CH3:24])(=[O:23])=[O:22])[C:15]=2[CH:14]=1

Participants

3

Reactant 2

HCID 691941946-(1-Methylphenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidineHCID 691968026-(4-Iodo-1-methyl-1H-imidazol-5-yl)-4-methylthio-thieno[2,3-d]pyrimidine2×

Product 1

HCID 691947766-(4-Iodo-1-methyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine

Procedure

The title compound was prepared by a similar process to that described for Intermediate 17 but using 6-(4-iodo-1-methyl-1H-imidazol-5-yl)-4-(methylthio)thieno[2,3-d]pyrimidine (Intermediate 93) in place of 6-(1-methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylthio)thieno[2,3-d]pyrimidine (example 7). Yellow solid (273 mg, 85%);

Sources & evidence

ORD record
ord-3b60419844df427881be241579d4e805
Source dataset
uspto-grants-2008_09
Patent number
US07427616B2

Reaction notes

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