6-(1-Methylphenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine → 6-(4-iodo-1-methyl-1H-imidazol-5-yl)thieno[2,3-d]pyrimidin-4-amine

HRID 32608Notes

Reaction equation

HRID 32608 reaction equation
[I:1][C:2]1[N:3]=[CH:4][N:5]([CH3:20])[C:6]=1[C:7]1[S:19][C:10]2[N:11]=[CH:12][N:13]=[C:14](S(C)(=O)=O)[C:9]=2[CH:8]=1.CC1([N:28]2C(C3SC4N=CN=C(S(C)(=O)=O)C=4C=3)=CN=C2)C=CC=CC1>>[I:1][C:2]1[N:3]=[CH:4][N:5]([CH3:20])[C:6]=1[C:7]1[S:19][C:10]2[N:11]=[CH:12][N:13]=[C:14]([NH2:28])[C:9]=2[CH:8]=1

Participants

3

Reactant 2

HCID 691941946-(1-Methylphenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidineHCID 691947766-(4-Iodo-1-methyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine2×

Product 1

HCID 691943866-(4-iodo-1-methyl-1H-imidazol-5-yl)thieno[2,3-d]pyrimidin-4-amine

Procedure

The title compound was prepared by a similar process to that described for Example 8 but using 6-(4-iodo-1-methyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine (Intermediate 94) in place of 6-(1-methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine (intermediate 17). Beige solid (143 mg, 85%);

Sources & evidence

ORD record
ord-e234f51f109e4e5eaf0019c229d972c1
Source dataset
uspto-grants-2008_09
Patent number
US07427616B2

Reaction notes

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