反应详情

A reaction mixture of 0.986 g of 3-amino-5-methyl-1,2,4-triazole and 2.178 g of 4,4,4-trifluoro-1-(3-pyridyl)-1,3-butanedione in 25 ml of glacial acetic acid was refluxed for 4 hours. The mixture was then evaporated to dryness in vacuo and gave a crystalline residue. This residue was partitioned between a saturated aqueous sodium bicarbonate solution and dichloromethane and the procedure of Example 1 was continued to give 1.33 g of the desired product as colorless crystals, mp 195°-197° C.

1. temperaturewas refluxed for 4 hours
2. customThe mixture was then evaporated to dryness in vacuo
3. customgave a crystalline residue
4. customThis residue was partitioned between a saturated aqueous sodium bicarbonate solution and dichloromethane