Benzoyl chloride → HCID 54486858, compound

Participants

Reaction Steps

12,2 g of 1-phenyl-pyrimido[1,6-a]indole-5-acetic acid ethyl ester (m.p. 59°-62°), obtained from 2-aminoethyl-indole-3-acetic acid ethyl ester and benzoylchloride and the resulting 1-phenyl-3,4-dihydro-pyrimido[1,6-a]indole-5-acetic acid ethyl ester (m.p. 83°-84°), are stirred with 30 ml of ethanol and 40 ml of 2n sodium hydroxide in the course of 3 hours at room temperature. The mixture is acidified with concentrated hydrochloric acid to pH=3 and 30 ml of propyleneoxide, while stirring, are added. After short time 1-phenyl-pyrimido[1,6-a]indole-5-acetic acid crystallises out and is filtered off. The acid is recrystallised from ethanol, m.p. 198-204 (decomposition).

Provenance & Evidence