Sodium Hydroxide → HCID 54005264, compound

Participants

Reaction Steps

To a solution of 2.8 g of 5-(7-ethoxycarbonyl- hept-6-enyl)imidazo[1,5-a]pyridine in 30 ml of methanol is added 15 ml of 1 N sodium hydroxide. The reaction is stirred at room temperature for 3 hours. The methanol is evaporated under reduced pressure and the residue diluted with 30 ml of water and the solution adjusted to pH 7 with 1 N hydrochloric acid. The solution is extracted with 2×50 ml of ethyl acetate. The combined ethyl acetate extracts are dried over anhydrous magnesium sulfate, filtered and the solvent evaporated under reduced pressure to yield 5-(7-carboxyhept-6-enyl)-imidazo-[1,5-a]pyridine melting at 110°-111°.

Provenance & Evidence