HCID 20446660, compound → HCID 20446656, compound

Participants

Reaction Steps

2-Cyano-4-(3-methoxycarbonylpropyl)pyridine (0.83 g) is hydrogenated at 3 atmospheres for 3 hours in 9 ml of methanol with 0.4 g of 10% palladium on charcoal. Filtration, evaporation, and preparative thin layer chromatography on silica gel with 1:1 methanol-ethyl acetate yields 2-aminomethyl-4-(3-methoxycarbonylpropyl)pyridine; Rf, 0.37 (EtOAc-MeOH 1:1, 1% NH4OH); NMR (CDCl3) 3.67 (s, 3 H), 4.15 (s, 2 H).

Provenance & Evidence