Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sulfolane | HCID 31347 | — |
| Reactant | Ethyl 2-chloro-3-[4-(2-methyl-2-phenylpropoxy)phenyl]propanoate | HCID 194150 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Solvent | Water | HCID 962 | — |
| Product | AL 321 | HCID 194620 | — |
Reaction Steps
A mixture of 27 g of ethyl 2-chloro-3-[4-(2-methyl-2-phenylpropyloxy)phenyl]propionate, 11 g of thiourea and 60 ml of sulfolane is heated at 110° C. for 6 hours and, then, boiled with 10 ml of 2 N-sulfuric acid (or 2 ml of 6 N-HCl) for 16 hours. After cooling, 1 l of water is added and the oil is separated and allowed to stand for a while, whereupon crystals separate out. These crystals are recrystallized from benzene-ligroin. By the above procedure is obtained 19.9 g of 5-[4-(2-methyl-2-phenylpropyloxy)benzyl]thiazolidine-2,4-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04444779 |
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| Source dataset | uspto-grants-1984_04 |
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| ORD ID | ord-b3633bcfc3fe43dab65b9b6183f569ee |
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| Source note | uspto-grants-1984_04 |
|---|
