関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Thiourea | HCID 2723790 | — |
| 反応物 | HCID 20462535 | HCID 20462535 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 5-[4-(4-Chlorobenzyloxy)benzyl]thiazolidine-2,4-dione | HCID 12944179 | — |
反応手順
In 2 ml of dimethylsulfoxide are dissolved 200 mg of 2-bromo-3-[4-(4-chlorobenzyloxy)phenyl]propionic acid and 100 mg of thiourea and the solution is heated at 110° C. for 3 hours. Then, after 0.5 ml of water is added, the solution is further heated for 5 hours. Then, 10 ml of water is added and the resulting crystals are recovered by filtration and recrystallized from benzene-n-hexane (1:1). By the above procedure is obtained 170 mg of 5-[4-(4-chlorobenzyloxy)benzyl]thiazolidine-2,4-dione.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04444779 |
|---|
| 出典データセット | uspto-grants-1984_04 |
|---|
| ORD ID | ord-048413fed7e74475983be6d763a6edda |
|---|
| 出典メモ | uspto-grants-1984_04 |
|---|
