Benzoyl chloride → N-Benzoyl-N-[2-(1-methyl-4-phenyl-1H-imidazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-yl]benzamide

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Reaction Steps

2-(1-Methyl-4-phenyl-1H-imidazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-amine (Example 2) (0.56 g) was dissolved in pyridine (10 mL), benzoyl chloride (0.44 mL) and triethylamine (0.28 mL) added then stirred at ambient temperature under an inert atmosphere. After 4 hours saturated aqueous NaHCO3 (10 mL) was added, the reaction mixture filtered, washed with water, EtOAc, diethyl ether and dried under high-vacuum to give the title compound as a colourless solid (0.63 g, 68%);

Provenance & Evidence