反应详情

400 parts of 2-chloro-p-xylene (b.p.=183° to 184° C.) and 2 parts of anhydrous aluminum chloride were charged into a 1-liter four-necked flask provided with a reflux condenser, a thermometer, a stirrer and a dropping funnel, to which 360 parts of bromine was dropwisely added over a period of 5 hours to carry out the reaction at 35° to 60° C. Water was added to the reaction liquid to wash the same with the thus added water and to remove the catalyst, and then the oil layer was cooled. The separated crystals were filtered, and washed with methanol to obtain 377 parts of 2-chloro-5-bromo-p-xylene having a melting point of 60° to 64° C.

1. customprovided with a reflux condenser
2. customthe reaction at 35° to 60° C
3. washto wash the same with the thus added water
4. customto remove the catalyst
5. temperaturethe oil layer was cooled
6. filtrationThe separated crystals were filtered
7. washwashed with methanol