[5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](cyclopropyl)methyl dimethylcarbamate → [5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](cyclopropyl)methanol

HRID 32618Notes

Reaction equation

HRID 32618 reaction equation
CN(C)C(=O)[O:4][CH:5]([C:9]1[N:10]([CH3:30])[C:11]([C:20]2[S:21][C:22]3[N:23]=[CH:24][N:25]=[C:26]([NH2:29])[C:27]=3[N:28]=2)=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:13]=1)[CH:6]1[CH2:8][CH2:7]1.CN(C)C(=O)OC(C1N(C)C(C2SC3N=CN=C(N)C=3N=2)=C(C2C=CC=CC=2)N=1)C1C=CC=CC=1>>[NH2:29][C:26]1[C:27]2[N:28]=[C:20]([C:11]3[N:10]([CH3:30])[C:9]([CH:5]([CH:6]4[CH2:7][CH2:8]4)[OH:4])=[N:13][C:12]=3[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[S:21][C:22]=2[N:23]=[CH:24][N:25]=1

Participants

3

Reactant 2

HCID 69196442[5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](cyclopropyl)methyl dimethylcarbamateHCID 69197371[5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](phenyl)methyl dimethylcarbamate2×

Product 1

HCID 9999715[5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](cyclopropyl)methanol

Procedure

The title compound was prepared by a similar process to that described for Example 104 but using [5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](cyclopropyl)methyl dimethylcarbamate. (Intermediate 98) in place of [5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](phenyl)methyl dimethylcarbamate (Intermediate 97). Colourless solid (6 mg, 66%);

Sources & evidence

ORD record
ord-b7c4d2f1b49c49f2915db00a6f659db1
Source dataset
uspto-grants-2008_09
Patent number
US07427616B2

Reaction notes

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