[5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](1,3-benzodioxol-4-yl)methyl dimethylcarbamate → [5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](1,3-benzodioxol-4-yl)methanol

HRID 32620Notes

Reaction equation

HRID 32620 reaction equation
CN(C)C(=O)[O:4][CH:5]([C:15]1[N:16]([CH3:36])[C:17]([C:26]2[S:27][C:28]3[N:29]=[CH:30][N:31]=[C:32]([NH2:35])[C:33]=3[N:34]=2)=[C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:19]=1)[C:6]1[C:14]2[O:13][CH2:12][O:11][C:10]=2[CH:9]=[CH:8][CH:7]=1.CN(C)C(=O)OC(C1N(C)C(C2SC3N=CN=C(N)C=3N=2)=C(C2C=CC=CC=2)N=1)C1C=CC=CC=1>>[NH2:35][C:32]1[C:33]2[N:34]=[C:26]([C:17]3[N:16]([CH3:36])[C:15]([CH:5]([C:6]4[C:14]5[O:13][CH2:12][O:11][C:10]=5[CH:9]=[CH:8][CH:7]=4)[OH:4])=[N:19][C:18]=3[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[S:27][C:28]=2[N:29]=[CH:30][N:31]=1

Participants

3

Reactant 2

HCID 69196031[5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](1,3-benzodioxol-4-yl)methyl dimethylcarbamate2×HCID 69197371[5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](phenyl)methyl dimethylcarbamate

Product 1

HCID 10095672[5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](1,3-benzodioxol-4-yl)methanol

Procedure

The title compound was prepared by a similar process to that described for Example 104 but using [5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](1,3-benzodioxol-4-yl)methyl dimethylcarbamate (Intermediate 99) in place of [5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](phenyl)methyl dimethylcarbamate (Intermediate 97). Colourless solid (5 mg, 54%);

Sources & evidence

ORD record
ord-342eac410af34c5d8b43200b0133c1a1
Source dataset
uspto-grants-2008_09
Patent number
US07427616B2

Reaction notes

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