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Potassium Carbonate → 8-tert-Butyl-2-(4-tert-butylpiperidinomethyl)-1,4-dioxaspiro[4,5]decane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Piperidine, 4-(1,1-dimethylethyl)- | HCID 74661 | — |
| 反応物 | HCID 14837662 | HCID 14837662 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 8-tert-Butyl-2-(4-tert-butylpiperidinomethyl)-1,4-dioxaspiro[4,5]decane | HCID 14837663 | — |
反応手順
17.4 g (123.6 mmol) of 4-tert-butylpiperidine, 9.0 g (30.9 mmol) of 8-tert-butyl-2-bromomethyl-1,4-dioxaspiro[4,5]decane (cis/trans mixture) and 4.3 g (30.9 mmol) of potassium carbonate in 100 ml of absolute dimethylformamide were heated at 150° C. for 8 hours. Some of the solvent was distilled off under reduced pressure, the residue was taken up with dilute aqueous sodium hydroxide solution/methylene chloride and the solution was worked up in a conventional manner.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05268351 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-25f8d9d80f324311aac41e586c631498 |
| 出典メモ | uspto-grants-1993_12 |