1-[5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl]-3-methylbutyl dimethylcarbamate → 1-[5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl]-3-methylbutan-1-ol

HRID 32622Notes

Reaction equation

HRID 32622 reaction equation
CN(C)C(=O)[O:4][CH:5]([C:10]1[N:11]([CH3:31])[C:12]([C:21]2[S:22][C:23]3[N:24]=[CH:25][N:26]=[C:27]([NH2:30])[C:28]=3[N:29]=2)=[C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:14]=1)[CH2:6][CH:7]([CH3:9])[CH3:8].CN(C)C(=O)OC(C1N(C)C(C2SC3N=CN=C(N)C=3N=2)=C(C2C=CC=CC=2)N=1)C1C=CC=CC=1>>[NH2:30][C:27]1[C:28]2[N:29]=[C:21]([C:12]3[N:11]([CH3:31])[C:10]([CH:5]([OH:4])[CH2:6][CH:7]([CH3:9])[CH3:8])=[N:14][C:13]=3[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[S:22][C:23]=2[N:24]=[CH:25][N:26]=1

Participants

3

Reactant 2

HCID 691963891-[5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl]-3-methylbutyl dimethylcarbamate2×HCID 69197371[5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](phenyl)methyl dimethylcarbamate

Product 1

HCID 691961971-[5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl]-3-methylbutan-1-ol

Procedure

The title compound was prepared by a similar process to that described for Example 104 but using 1-[5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl]-3-methylbutyl dimethylcarbamate (Intermediate 100) in place of [5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](phenyl)methyl dimethylcarbamate (Intermediate 97). Colourless solid (5 mg, 63%);

Sources & evidence

ORD record
ord-d1ca41ee43bf439d961b62e2b055048a
Source dataset
uspto-grants-2008_09
Patent number
US07427616B2

Reaction notes

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