[5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](1-methyl-1H-imidazol-2-yl)methyl dimethylcarbamate → [5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](1-methyl-1H-imidazol-2-yl)methanol

HRID 32624Notes

Reaction equation

HRID 32624 reaction equation
CN(C)C(=O)[O:4][CH:5]([C:12]1[N:13]([CH3:33])[C:14]([C:23]2[S:24][C:25]3[N:26]=[CH:27][N:28]=[C:29]([NH2:32])[C:30]=3[N:31]=2)=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:16]=1)[C:6]1[N:7]([CH3:11])[CH:8]=[CH:9][N:10]=1.CN(C)C(=O)OC(C1N(C)C(C2SC3N=CN=C(N)C=3N=2)=C(C2C=CC=CC=2)N=1)C1C=CC=CC=1>>[NH2:32][C:29]1[C:30]2[N:31]=[C:23]([C:14]3[N:13]([CH3:33])[C:12]([CH:5]([C:6]4[N:7]([CH3:11])[CH:8]=[CH:9][N:10]=4)[OH:4])=[N:16][C:15]=3[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[S:24][C:25]=2[N:26]=[CH:27][N:28]=1

Participants

3

Reactant 2

HCID 69196145[5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](1-methyl-1H-imidazol-2-yl)methyl dimethylcarbamate2×HCID 69197371[5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](phenyl)methyl dimethylcarbamate

Product 1

HCID 69195653[5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](1-methyl-1H-imidazol-2-yl)methanol

Procedure

The title compound was prepared by a similar process to that described for Example 104 but using [5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](1-methyl-1H-imidazol-2-yl)methyl dimethylcarbamate (Intermediate 101) in place of [5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl](phenyl)methyl dimethylcarbamate (Intermediate 97). Colourless solid (20 mg, 82%);

Sources & evidence

ORD record
ord-3a772618a5c74a9da2445d66171cc14e
Source dataset
uspto-grants-2008_09
Patent number
US07427616B2

Reaction notes

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