反应详情

A mixture of 8.6 parts of 7-quinolinemethanol, 20 parts of manganese(IV)oxide and 130 parts of dichloromethane was stirred for 24 hours at room temperature. The reaction mixture was filtered over diatomaceous earth and the filtrate was evaporated. The residue was purified by column chromatography (silica gel; CH2Cl2 /CH3OH 98:2). The eluent of the desired fraction was evaporated, yielding 8 parts (94.2%) of 7-quinolinecarboxaldehyde; mp. 56° C. (interm. 1).

1. filtrationThe reaction mixture was filtered over diatomaceous earth
2. customthe filtrate was evaporated
3. customThe residue was purified by column chromatography (silica gel; CH2Cl2 /CH3OH 98:2)
4. customThe eluent of the desired fraction was evaporated