HCID 19967111, compound → HCID 22335511, compound

HRID 326258Notes

Reaction equation

HRID 326258 reaction equation
[CH3:1][CH:2]([CH3:18])[CH:3]([N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1)[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[CH:6][CH:5]=1>[Ni].CO>[N:13]1([CH:3]([C:4]2[CH:5]=[CH:6][C:7]([NH2:10])=[CH:8][CH:9]=2)[CH:2]([CH3:18])[CH3:1])[CH:17]=[CH:16][N:15]=[CH:14]1

Participants

4

Reactant 1

HCID 19967111HCID 19967111, compound

Product 1

HCID 22335511HCID 22335511, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A mixture of 12 parts of intermediate 40, namely 1-[2-methyl-1-(4-nitrophenyl)-propyl]-1H-imidazole, and 79 parts of methanol was hydrogenated for 1 hour at room temperature and 2.105Pa with 3 parts of Raney nickel. The catalyst was filtered off and the filtrate was evaporated, yielding 12 parts (100%) of 4-[1-(1H-imidazol-1-yl)-2-methylpropyl]benzenamine (interm. 41).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-309cc619773d4c4390f0e42b915eddb4
Source dataset
uspto-grants-1993_12
Patent number
US05268380

Reaction notes

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