HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[(4-Nitrophenyl)(phenyl)methyl]-1H-imidazole → 4-((1H-Imidazol-1-yl)(phenyl)methyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[(4-Nitrophenyl)(phenyl)methyl]-1H-imidazole | HCID 14174067 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-((1H-Imidazol-1-yl)(phenyl)methyl)aniline | HCID 14174069 | 99.1% |
Reaction Steps
A solution of 39 parts of intermediate 42, namely 1-[(4-nitrophenyl)phenylmethyl]-1H-imidazole, in 240 parts of ethanol was hydrogenated at 3.105Pa and at room temperature with 20 parts of Raney nickel. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 34.6 parts (99.1%) of 4-[(1H-imidazol-1-yl)phenylmethyl]-benzenamine (interm. 43).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05268380 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-5fff2741624644cca0839e63868261e3 |
| Source note | uspto-grants-1993_12 |