Ethanolamine → 2-[5-(7-Methylthio[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-4-phenyl-1H-imidazol-1-yl]ethanol

Participants

Role	Name	HCID	Charge
Reactant	Ethanolamine	HCID 700	—
Reactant	4-(Methylthio)thieno[2,3-d]pyrimidine-6-carbaldehyde	HCID 17965859	—
Reactant	6-(1-ethyl-4-phenyl-1H-imidazol-5-yl)-4-(methylthio)thieno[2,3-d]pyrimidine	HCID 69194927	—
Reactant	2-(1-ethyl-4-phenyl-1H-imidazol-5-yl)-7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine	HCID 69196002	—
Product	2-[5-(7-Methylthio[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-4-phenyl-1H-imidazol-1-yl]ethanol	HCID 69196859	—

Reaction Steps

The title compound was prepared by a similar process to that described for Intermediate 70 but using 7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine-2-carbaldehyde (Intermediate 78) in place of 4-(methylthio)thieno[2,3-d]pyrimidine-6-carbaldehyde (Intermediate 15) and ethanolamine in place of ethylamine. Colourless solid (52 mg, 56%);

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07427616B2
Source dataset	uspto-grants-2008_09
ORD ID	ord-b4c598ef4e1e4e2fb534e61db48d0f35
Source note	uspto-grants-2008_09