1-(2-Hydroxy-5-methoxyphenyl)ethan-1-one → HCID 19736723, compound

Participants

Reaction Steps

A solution of (2'-hydroxy-5'methoxyphenyl)ethanone (3.32 g, 20 mmol) and cyclohexanonepyrrolidine (enamine form) (3.18 g, 21 mmol) in dry ethanol (40 ml) is heated to reflux for 1.5 hours under nitrogen gas. The solvent is removed by distillation, and the residue is dissolved in diethyl ether, washed with dilute HCl and then water, dried, and concentrated. The residue is placed on a silica gel column and eluted with a mixture of ethyl acetate and hexane (1:2) to obtain the title compound as thick syrup (4.5 g, yield 91.3%). ##STR8##

Provenance & Evidence