HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Iodophenyl)(isocyano)methyl 4-methylphenyl sulfone → a-Tosyl-(4-methoxybenzyl) isocyanide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Iodophenyl)(isocyano)methyl 4-methylphenyl sulfone | HCID 17965763 | — |
| Reactant | 2-{1-Methyl-4-phenyl-2-[(trimethylsilyl)ethynyl]-1H-imidazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-amine | HCID 69194173 | — |
| Reactant | {(3-Iodophenyl)[(4-methylphenyl)sulfonyl]methyl}formamide | HCID 85929703 | — |
| Product | a-Tosyl-(4-methoxybenzyl) isocyanide | HCID 2771655 | — |
Reaction Steps
The title compound was prepared by a similar process to that described for Intermediate 53 but using (4-methoxyphenyl)(phenylsulfonyl)methylformamide (Tetrahedron Lett., 1996, 37 (45), 8113) in place of {(3-iodophenyl)[(4-methylphenyl)sulfonyl]methyl}formamide (Intermediate 52). Tan solid (26.15 g, 97%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427616B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-f3e9bbdf3bf645ebbbf2ee85215dbf78 |
| Source note | uspto-grants-2008_09 |