反应详情

A solution of trimethylacetyl chloride (2.53 g, 0.021 mole) and 1-methylethyl 5-amino-2-chloro-4-fluorobenzoate (4.62 g, 0.020 mole) in methyl ethyl ketone was stirred at room temperature for 16 hours and then refluxed for 2 hours. The solvent was removed and the residue triturated with diethyl ether to give a tan solid, m.p. 81°-83° C. (5.0 g, 79% yield).

1. temperaturerefluxed for 2 hours
2. customThe solvent was removed
3. customthe residue triturated with diethyl ether
4. customto give a tan solid, m.p. 81°-83° C. (5.0 g, 79% yield)