反应详情

A mixture of 2-undecanone (10 g, 58.7 mmol), glyoxylic acid monohydrate (5.15 g, 56 mmol) and 85% phosphoric acid (10 ml) was warmed at 80° for 18 hours. On cooling to room temperature, the mixture was diluted with ethyl ether/dichloromethane (50 ml each) and washed thoroughly with brine. Evaporation of the dried (magnesium sulphate) organic phase gave a yellow oil which on crystallization from ethyl ether/petroleum ether gave 4-ketotridec-2-enoic acid as colorless prisms.

1. temperaturewas warmed at 80° for 18 hours
2. washwashed thoroughly with brine
3. customEvaporation of the
4. dry with materialdried (magnesium sulphate) organic phase
5. customgave a yellow oil which
6. customon crystallization from ethyl ether/petroleum ether