6-(1-Methylphenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine → 6-[4-(4-Methoxyphenyl)-1-methyl-1H-imidazol-5-yl]-4-(methylsulfonyl)thieno[2,3-d]pyrimidine

HRID 32636Notes

Reaction equation

HRID 32636 reaction equation
C[C:2]1([N:8]2[C:12]([C:13]3[S:25][C:16]4[N:17]=[CH:18][N:19]=[C:20]([S:21]([CH3:24])(=[O:23])=[O:22])[C:15]=4[CH:14]=3)=[CH:11][N:10]=[CH:9]2)C=CC=CC1.[CH3:26][O:27][C:28]1[CH:33]=[CH:32][C:31](C2N=CN(C)C=2C2SC3N=CN=C(SC)C=3C=2)=[CH:30][CH:29]=1>>[CH3:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([C:11]2[N:10]=[CH:9][N:8]([CH3:2])[C:12]=2[C:13]2[S:25][C:16]3[N:17]=[CH:18][N:19]=[C:20]([S:21]([CH3:24])(=[O:22])=[O:23])[C:15]=3[CH:14]=2)=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 691941946-(1-Methylphenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidineHCID 691962606-[4-(4-methoxyphenyl)-1-methyl-1H-imidazol-5-yl]-4-(methylthio)thieno[2,3-d]pyrimidine2×

Product 1

HCID 691965576-[4-(4-Methoxyphenyl)-1-methyl-1H-imidazol-5-yl]-4-(methylsulfonyl)thieno[2,3-d]pyrimidine

Procedure

The title compound was prepared by a similar process to that described for Intermediate 17 but using 6-[4-(4-methoxyphenyl)-1-methyl-1H-imidazol-5-yl]-4-(methylthio)thieno[2,3-d]pyrimidine (Intermediate 105) in place of 6-(1-methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylthio)thieno[2,3-d]pyrimidine (Example 7). Brown gum (3.13 g, 100%);

Sources & evidence

ORD record
ord-3a8549a9cc44469d8975b27ded1d11c9
Source dataset
uspto-grants-2008_09
Patent number
US07427616B2

Reaction notes

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