反应详情

Boron tribromide (1.0M in DCM) (10.1 mL) was added dropwise to 6-[4-(4-methoxyphenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine (Intermediate 107) (0.91 g) in DCM (20 mL) then stirred for 5 days at ambient temperature. The reaction mixture was concentrated in vacuo and the residue partitioned between DCM and water. The aqueous layer was separated and extracted with DCM (3×20 mL), the aqueous layer was then adjusted to pH 9 with concentrated aqueous NH3, the resultant solid filtered and dried in vacuo to give the title compound as a brown solid (623 mg, 71%);

1. concentrationThe reaction mixture was concentrated in vacuo
2. customthe residue partitioned between DCM and water
3. customThe aqueous layer was separated
4. extractionextracted with DCM (3×20 mL)
5. filtrationthe resultant solid filtered
6. customdried in vacuo