HCID 19736548, compound → HCID 19736554, compound

Participants

Reaction Steps

Methyl 2-n-butyl-5-benzyloxycarbonyl-1-{2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl}methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-6-carboxylate (1.26 g) and a catalytic amount of 10 % palladium-carbon are added to methanol (300 ml), and the mixture is stirred under hydrogen atmosphere. After the reaction is completed, palladium-carbon is removed by filtration, and the filtrate is evaporated under reduced pressure to give methyl 2-n-butyl-1-{2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl}methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-6-carboxylate (0.94 g) as foam.

Provenance & Evidence