Cyanoacetic acid → HCID 19736553, compound

Participants

Reaction Steps

A mixture of methyl 2-n-butyl-1-{2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl}methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-6-carboxylate (0.81 g), dicyclohexyl-carbodiimide (0.26 g), 1-hydroxybenzotriazole (0.17 g), cyanoacetic acid (0.11 g) and acetonitrile (10 ml) is stirred at room temperature overnight. After the reaction is completed, ethyl acetate is added to the reaction mixture, and the mixture is waehed with aqueous sodium hydrogen carbonate solution, dried, and the solvent is distilled off under reduced pressure. The resulting residue is purified by silica gel column chromatography (solvent; ethyl acetate) to give methyl 2-n-butyl-5-cyanoacetyl-1-{2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl}methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-6-carboxylate (0.83 g) as foam.

Provenance & Evidence