Ethyl 3-chloro-3-oxopropionate → HCID 19736528, compound

HRID 326453Notes

Reaction equation

HRID 326453 reaction equation
[CH2:1]([C:5]1[N:17]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]3[N:35]([C:36]([C:49]4[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=4)([C:43]4[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=4)[C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=4)[N:34]=[N:33][N:32]=3)=[CH:21][CH:20]=2)[C:8]2[CH2:9][NH:10][CH:11]([C:13]([O:15][CH3:16])=[O:14])[CH2:12][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4].[CH2:55]([O:57][C:58]([CH2:60][C:61](Cl)=[O:62])=[O:59])[CH3:56]>>[CH2:1]([C:5]1[N:17]([CH2:18][C:19]2[CH:20]=[CH:21][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]3[N:35]([C:36]([C:43]4[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=4)([C:37]4[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=4)[C:49]4[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=4)[N:34]=[N:33][N:32]=3)=[CH:23][CH:24]=2)[C:8]2[CH2:9][N:10]([C:61](=[O:62])[CH2:60][C:58]([O:57][CH2:55][CH3:56])=[O:59])[CH:11]([C:13]([O:15][CH3:16])=[O:14])[CH2:12][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 118931Ethyl 3-chloro-3-oxopropionateHCID 19736540HCID 19736540, compound

Product 1

HCID 19736528HCID 19736528, compound

Procedure

Methyl 2-n-butyl-3-{2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl}methyl-4,5,6,7-tetrahydroimidazo[4,5-c]-pyridine-6-carboxylate and ethoxycarbonylacetyl chloride are treated in the same manner as in Example 1-(2) to give methyl 2-n-butyl-5-ethoxycarbonylacetyl-3-{2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl}methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-6-carboxylate.

Sources & evidence

ORD record
ord-2ecb84521f4a4d93940f990040891c43
Source dataset
uspto-grants-1993_12
Patent number
US05268377

Reaction notes

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