Monoethyl malonate → HCID 178439979, compound

HRID 326459Notes

Reaction equation

[CH2:1]([C:4]1[N:16]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[C:30]3[NH:34][N:33]=[N:32][N:31]=3)=[CH:20][CH:19]=2)[C:7]2[CH:8]([C:12]([O:14][CH3:15])=[O:13])[NH:9][CH2:10][CH2:11][C:6]=2[N:5]=1)[CH2:2][CH3:3].[CH2:35]([O:37][C:38]([CH2:40][C:41](O)=[O:42])=[O:39])[CH3:36]>>[CH2:1]([C:4]1[N:16]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[C:30]3[NH:34][N:33]=[N:32][N:31]=3)=[CH:20][CH:19]=2)[C:7]2[CH:8]([C:12]([O:14][CH3:15])=[O:13])[N:9]([C:41](=[O:42])[CH2:40][C:38]([O:37][CH2:35][CH3:36])=[O:39])[CH2:10][CH2:11][C:6]=2[N:5]=1)[CH2:2][CH3:3]

Participants

Reactant 2

HCID 70615Monoethyl malonate

HCID 178439978HCID 178439978, compound

Product 1

HCID 178439979HCID 178439979, compound

Procedure

Methyl 2-n-propyl-3-{2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]-pyridine-4-carboxylate and ethoxycarbonylacetic acid are treated in the same manner as in Example 8-(1) to give methyl 2-n-propyl-5-ethoxycarbonylacetyl-3-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]-pyridine-4-carboxylate.

Sources & evidence

ORD record: ord-6784ed623aa543f89f4a277abf0c363d
Source dataset: uspto-grants-1993_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05268377

Reaction notes

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