Methyl 4'-(bromomethyl)biphenyl-2-carboxylate → HCID 19932971, compound

HRID 326467Notes

Reaction equation

HRID 326467 reaction equation
[CH2:1]([C:5]1[NH:6][CH:7]=[C:8]([CH2:10][CH2:11][NH:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[N:9]=1)[CH2:2][CH2:3][CH3:4].[CH3:20][O:21][C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[C:30]1[CH:35]=[CH:34][C:33]([CH2:36]Br)=[CH:32][CH:31]=1)=[O:23]>>[CH2:1]([C:5]1[N:6]([CH2:36][C:33]2[CH:34]=[CH:35][C:30]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[C:22]([O:21][CH3:20])=[O:23])=[CH:31][CH:32]=2)[CH:7]=[C:8]([CH2:10][CH2:11][NH:12][C:13]([O:15][C:16]([CH3:18])([CH3:17])[CH3:19])=[O:14])[N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 11012181Methyl 4'-(bromomethyl)biphenyl-2-carboxylateHCID 178441649HCID 178441649, compound

Product 1

HCID 19932971HCID 19932971, compound

Procedure

2-n-Butyl-4-{2-(t-butoxycarbonylamino)ethyl}-imidazole and 2'-(methoxycarbonyl)biphenyl-4-ylmethyl bromide are treated in the same manner as in Reference Example 1-(6) except that the reaction is carried out overnight to give 2-n-butyl-4-{2-(t-butoxycarbonylamino)-ethyl}-1-{2'-(methoxycarbonyl)biphenyl-4-yl}methylimidazole.

Sources & evidence

ORD record
ord-49c32d068dff4b978f132a79e0310fcd
Source dataset
uspto-grants-1993_12
Patent number
US05268377

Reaction notes

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